An antimalarial agent with anticancer activity; an iron(II) oxide-reactive endoperoxide that generates ROS; reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM); reduces parasitemia in mice infected with P. falciparum (CD50 = 140 mg/kg); reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day); inhibits growth of SK-N-AS

Artemisinin – 500 mg

Brand:
Cayman
CAS:
63968-64-9
Storage:
-20
UN-No:
Non-Hazardous - /

Artemisinin is an antimalarial agent with anticancer activity.{21232,37702} It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge.{35319} It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg.{21232,37703} It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day).{37704} Artemisinin (100-400 μM) induces cell cycle arrest in the G0/G1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner.{37702} It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria.  

 

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Description

An antimalarial agent with anticancer activity; an iron(II) oxide-reactive endoperoxide that generates ROS; reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM); reduces parasitemia in mice infected with P. falciparum (CD50 = 140 mg/kg); reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day); inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells from 100-400 μM; suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model

Formal name: (3R,5aS,6R,8aS,9R,12S,12aR)-octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one

Synonyms:  NSC 369397

Molecular weight: 282.3

CAS: 63968-64-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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