An amino acid with antidiabetic activity; increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas at 200 μM; increases PI3K activity in muscle and liver in rats at 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide and STZ at 25 mg/kg; decreases plasma glucose

4-Hydroxyisoleucine – 5 mg

Brand:
Cayman
CAS:
55399-93-4
Storage:
-20
UN-No:
Non-Hazardous - /

4-Hydroxyisoleucine is an amino acid that has been found in fenugreek (T. foenum graecum) seeds and has antidiabetic activity.{51117,51118,51119} It increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas when used at a concentration of 200 μM.{51117} In vivo, 4-hydroxyisoleucine increases PI3K activity in muscle and liver in rats when administered at a dose of 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide (Item No. 11127) and streptozotocin (STZ; Item No. 13104) when administered at 25 mg/kg.{51118} 4-Hydroxyisoleucine (50 mg/kg per day for four weeks) decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes.{51119}  

 

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SKU: 11812 - 5 mg Category:

Description

An amino acid with antidiabetic activity; increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas at 200 μM; increases PI3K activity in muscle and liver in rats at 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide and STZ at 25 mg/kg; decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes at 50 mg/kg per day for four weeks

Formal name: 2-amino-2,3,5-trideoxy-3-methyl-L-ribonic acid

Synonyms:  (4S)-4-Hydroxy-L-isoleucine|4-OH-Ile

Molecular weight: 147.2

CAS: 55399-93-4

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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