An inhibitor of TORC1/2

INK128 – 5 mg

Brand:
Cayman
CAS:
1224844-38-5
Storage:
-20
UN-No:
Non-Hazardous - /

INK128 is an inhibitor of TORC1/2, acting as an ATP-dependent inhibitor of mTOR kinase (IC50 = 1 nM).{31895,21344,21346} It blocks the phosphorylation of downstream substrates of both TORC1 and TORC2.{21344} INK128 interferes with the growth of cell lines which are resistant to rapamycin and pan-PI3K inhibitors.{21344,21345} Moreover, daily, oral administration of INK128 inhibits angiogenesis and tumor growth in several xenograft models.{21344} The effects of INK128 on gene expression also reduce invasion and metastasis.{20985}  

 

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SKU: 11811 - 5 mg Category:

Description

An inhibitor of TORC1/2, acting as a sub-nanomolar ATP-dependent inhibitor of mTOR kinase; interferes with the growth of cell lines which are resistant to rapamycin and pan-PI3K inhibitors; inhibits angiogenesis and tumor growth in several xenograft models; reduces invasion and metastasis

Formal name: 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Synonyms:  MLN0128

Molecular weight: 309.3

CAS: 1224844-38-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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