A withanolide; identified as an nNOS inhibitor in an in silico docking study (Ki = 5.15 nM) that also inhibits iNOS and eNOS (Kis = 15.48 and 66.59 nM

Withanolide B – 5 mg

Brand:
Cayman
CAS:
56973-41-2
Storage:
-20
UN-No:
Non-Hazardous - /

Withanolide B is a withanolide that has been found in W. somnifera.{48147} Unlike withanolide A, it does not increase glucose uptake in L6 myotubes.{48148} In in silico docking studies, withanolide B was identified as a neuronal nitric oxide synthase (nNOS) inhibitor (Ki = 5.15 nM), that also inhibited inducible NOS (iNOS) and endothelial NOS (eNOS; Kis = 15.48 and 66.59 nM, respectively), and as a ligand for the PARP1 catalytic domain with an estimated Ki value of 7.54 nM.{48150,48149}  

 

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SKU: 11798 - 5 mg Category:

Description

A withanolide; identified as an nNOS inhibitor in an in silico docking study (Ki = 5.15 nM) that also inhibits iNOS and eNOS (Kis = 15.48 and 66.59 nM, respectively); identified as a ligand for the PARP1 catalytic domain in an in silico docking study with an estimated Ki value of 7.54 nM

Formal name: 6α,7α-epoxy-5α,22R-dihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, δ-lactone

Synonyms: 

Molecular weight: 454.6

CAS: 56973-41-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nitric Oxide Synthases||Research Area|Neuroscience

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