An antimitotic vinca alkaloid which irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization; exported from cells via the ABC transporter P-glycoprotein but not by Mrp1

Vincristine (sulfate) – 5 mg

Brand:
Cayman
CAS:
2068-78-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Vincristine is an antimitotic vinca alkaloid, isolated from the plant V. rosea. It irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization.{21119,21120} Vincristine is exported from cells via the ATP-binding cassette transporter P-glycoprotein, but not by multidrug resistance-associated protein.{21121} Its effectiveness in blocking the proliferation of cancer cells is affected by overexpression of P-glycoprotein.{21122}  

 

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SKU: 11764 - 5 mg Category:

Description

An antimitotic vinca alkaloid which irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization; exported from cells via the ABC transporter P-glycoprotein but not by Mrp1

Formal name: 22-oxo-vincaleukoblastine sulfate

Synonyms:  Kyocristine|Leurocristine|Lilly 37231|Novopharm|NSC 67574|Oncovin|VCR

Molecular weight: 923

CAS: 2068-78-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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