A nonpeptidomimetic

Tipifarnib – 5 mg

Brand:
Cayman
CAS:
192185-72-1
Storage:
-20
UN-No:
Non-Hazardous - /

Tipifarnib is a nonpeptidomimetic, CAAX-competitive inhibitor of farnesyltransferase (IC50 = 0.86 nM).{33516} It prevents farnesylation of Ras GTPases and has shown potent efficacy in various in vitro and in vivo tumor models.{21247,21707}  

 

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SKU: 11747 - 5 mg Category:

Description

A nonpeptidomimetic, CAAX-competitive inhibitor of farnesyltransferase (IC50 = 0.86 nM); prevents farnesylation of Ras GTPases and has shown potent efficacy in various in vitro and in vivo tumor models

Formal name: 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone

Synonyms:  R 115777

Molecular weight: 489.4

CAS: 192185-72-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling|GTPases||Research Area|Cell Biology|Cell Signaling|GTPases

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