A cannabinoid CB1 receptor antagonist (Kis = 224 and >10

LY320135 – 1 mg

Brand:
Cayman
CAS:
176977-56-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

LY320135 is a selective cannabinoid (CB) receptor 1 antagonist (Kis = 224 and >10,000 nM for CB1 and CB2, respectively, in vitro).{36501} It is selective for CB1 over α1- and α2- adrenergic, D1 and D2 dopamine, benzodiazepine, histamine H1, GABA, serotonin (5-HT), and muscarinic receptors. It reverses the inhibition of forskolin-induced cAMP accumulation induced by arachidonoyl ethanolamide (anandamide; Item No. 90050) in CHO cells and inhibits a stimulatory effect of arachidonoyl ethanolamide on adenylate cyclase induced by application of pertussis toxin (IC50 = 734 nM). LY320135 (1 mg/kg) reverses inhibition of light-induced phase shifts in hamsters induced by the CB1 agonist CP 55,940 (Item No. 90084).{36502}  

 

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SKU: 11738 - 1 mg Category:

Description

A cannabinoid CB1 receptor antagonist (Kis = 224 and >10,000 nM for CB1 and CB2, respectively); selective for CB1 over α1- and α2- adrenergic, D1 and D2 dopamine, benzodiazepine, histamine H1, GABA, 5-HT, and muscarinic receptors; reverses the inhibition of forskolin-induced cAMP accumulation induced by arachidonoyl ethanolamide (anandamide); reverses inhibition of light-induced phase shifts in hamsters induced by the CB1 agonist CP 55,940 when used at a dose of 1 mg/kg

Formal name: 4-[[6-methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]-benzonitrile

Synonyms: 

Molecular weight: 383.4

CAS: 176977-56-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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