A phytoestrogen that competitively (vs. 17β-estradiol) binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells; a weak antagonist of pregnane X receptor (IC50 = 12 μM)

Coumestrol – 5 mg

Brand:
Cayman
CAS:
479-13-0
Storage:
-20
UN-No:
Non-Hazardous - /

Coumestrol is a phytoestrogen that occurs naturally in soybeans, spinach, and clover. It competitively (vs. 17β-estradiol, Item No. 10006315) binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells.{22350,22351} Coumestrol is also a weak antagonist of pregnane X receptor (IC50 = 12 μM) as well as a potential inverse agonist of the constitutive androstane receptor (EC50 = 30 μM).{22352}  

 

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SKU: 11730 - 5 mg Category:

Description

A phytoestrogen that competitively (vs. 17β-estradiol) binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells; a weak antagonist of pregnane X receptor (IC50 = 12 μM)

Formal name: 3,9-dihydroxy-6H-benzofuro[3,2-c][1]benzopyran-6-one

Synonyms:  NSC 22842

Molecular weight: 268.2

CAS: 479-13-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Phytosterols||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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