A natural product and metabolite of curcumin; has anti-inflammatory

Hexahydrocurcumin – 5 mg

Brand:
Cayman
CAS:
36062-05-2
Storage:
-20
UN-No:
Non-Hazardous - /

Hexahydrocurcumin is a natural product and glucuronide metabolite of curcumin that has anti-inflammatory, antioxidant, and anticancer properties.{8985} It reduces prostaglandin E2 (PGE2) production stimulated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) by 37% in human colonic epithelial cells when used at a concentration of 20 µM. Hexahydrocurcumin (3.125-25 µM) inhibits overproduction of nitric oxide induced by LPS in RAW 264.7 macrophage cells in a concentration-dependent manner.{38854} It does not affect LPS-induced cytokine release but inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation when used at a concentration of 50 µM. Hexahydrocurcumin prevents the formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer and potentiates the effect of 5-fluorouracil (Item No. 14416).{38855}  

 

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Description

A natural product and metabolite of curcumin; has anti-inflammatory, antioxidant, and anticancer properties; reduces PMA-induced PGE2 production by 37% in human colonic epithelial cells (20 µM); inhibits LPS-induced overproduction of nitric oxide in RAW 264.7 macrophage cells (3.125-25 µM); inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation (50 µM); prevents formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer

Formal name: 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone

Synonyms: 

Molecular weight: 374.4

CAS: 36062-05-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen|iNOS

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