A triterpene with anticancer activity; inhibits growth of NSCLC A549 cells (IC50 = 6.92 µM) in vitro; induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner; inhibits phosphorylation of p42/44

β-Elemonic Acid – 10 mg

Brand:
Cayman
CAS:
28282-25-9
Storage:
-20
UN-No:
Non-Hazardous - /

β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity.{35033,35034} It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 µM) in vitro.{35034} β-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression in vitro. β-Elemonic acid also inhibits prolyl endopeptidase (IC50 = 39.74 µM) in vitro.{35033}  

 

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SKU: 11712 - 10 mg Category:

Description

A triterpene with anticancer activity; inhibits growth of NSCLC A549 cells (IC50 = 6.92 µM) in vitro; induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner; inhibits phosphorylation of p42/44, MAPK/JNK, and p38 in vitro; induces ROS production and COX-2 expression in vitro; inhibits prolyl endopeptidase (IC50 = 39.74 µM) in vitro,

Formal name: 3-oxo-(13α,14β,17α,20S)-lanosta-8,24-dien-21-oic acid

Synonyms:  3-oxo Tirucallic Acid|3-Oxotirucallenoic Acid|Elemadienonic Acid

Molecular weight: 454.7

CAS: 28282-25-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer|Cell Death|Apoptosis

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