A natural macrocyclic peptide which potently inhibits the proliferation of PC3 prostate carcinoma cells (IC50 = 35 nM) by binding F-actin (KD = 15 nM); stabilizes actin filaments in vitro but disrupts actin filaments and induces irregular polymerization of monomeric actin in vivo

Jasplakinolide – 100 µg

Brand:
Cayman
CAS:
102396-24-7
Storage:
-20
UN-No:
Non-Hazardous - /

Jasplakinolide is a natural macrocyclic peptide first isolated from a marine sponge. It potently inhibits the proliferation of PC3 prostate carcinoma cells (IC50 = 35 nM) by binding F-actin (KD = 15 nM).{22599} This binding of jasplakinolide to actin, which is competitive with phalloidin, stabilizes actin filaments in vitro but disrupts actin filaments and induces irregular polymerization of monomeric actin in vivo.{22599,22598} This compound is used to investigate the role of actin in diverse cellular roles, such as motility, transport, and development.{22600,22601}  

 

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SKU: 11705 - 100 µg Category:

Description

A natural macrocyclic peptide which potently inhibits the proliferation of PC3 prostate carcinoma cells (IC50 = 35 nM) by binding F-actin (KD = 15 nM); stabilizes actin filaments in vitro but disrupts actin filaments and induces irregular polymerization of monomeric actin in vivo

Formal name: cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-8S-hydroxy-2S,4E,6R-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]

Synonyms:  NSC 613009

Molecular weight: 709.7

CAS: 102396-24-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Peptides||Research Area|Cancer||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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