An anticancer nucleoside analog; inhibits the growth of HL-60 promyelocytic leukemia cells (LC50 = 40 nM); inhibits the growth of MX-1 mammary

Gemcitabine – 100 mg

Brand:
Cayman
CAS:
95058-81-4
Storage:
-20
UN-No:
Non-Hazardous - /

Gemcitabine is an anticancer nucleoside analog that inhibits the growth of HL-60 promyelocytic leukemia cells with an LC50 value of 40 nM.{40344} It inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and HS766T, PaCa-2, PANC-1, and BxPC-3 pancreatic cancer tumors in mouse xenograft models (45-93% inhibition).{40343} Gemcitabine is a prodrug that is metabolized to a diphosphate and triphosphate form in cells. The triphosphate form is incorporated into DNA which induces masked chain termination and cell death.{21021} By specifically inhibiting growth arrest and DNA damage inducible protein 45 a (Gadd45a), a key mediator of active DNA demethylation, gemcitabine, at concentrations ranging from 34 to 134 nM, inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay. Gemcitabine also has broad antiretroviral activity, decreasing MuLV cell infectivity, a murine AIDS model, in cell culture (EC50 = ~1.5 nM) and inhibits the progression of murine AIDS in vivo at a dose of 1-2 mg/kg per day.{21022}  

 

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Description

An anticancer nucleoside analog; inhibits the growth of HL-60 promyelocytic leukemia cells (LC50 = 40 nM); inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and HS766T, PaCa-2, PANC-1, and BxPC-3 pancreatic cancer tumors in mouse xenograft models (45-93% inhibition); inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay; decreases MuLV cell infectivity (EC50 = ~1.5 nM); inhibits the progression of murine AIDS in vivo,

Formal name: 2′-deoxy-2′,2′-difluoro-cytidine

Synonyms:  DDFC|LY 188011|NSC 613327

Molecular weight: 263.2

CAS: 95058-81-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Nucleotides/Nucleosides||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair||Research Area|Epigenetics, Transcription, & Translation|Writers|DNA/RNA Methylation||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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