A pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor

Indiplon – 5 mg

Brand:
Cayman
CAS:
325715-02-4
Storage:
-20
UN-No:
Non-Hazardous - /

Indiplon is a pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner.{25527,25525} Indiplon is selective for α1 subunits (EC50 = 2.6 nM) as compared with α2, α3, or α5 (EC50 = 24, 60, and 77 nM).{25527,25525} Through this action, indiplon has sedative and hypnotic effects that can improve sleep onset, maintenance, and duration.{25528,25526}  

 

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SKU: 11638 - 5 mg Category:

Description

A pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner; selective for α1 subunits (EC50 = 2.6 nM) as compared with α2, α3, or α5 (EC50 = 24, 60, and 77 nM)

Formal name: N-methyl-N-[3-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-acetamide

Synonyms:  NBI 34060

Molecular weight: 376.4

CAS: 325715-02-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation||Research Area|Neuroscience|Behavioral Neuroscience

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