A potent inhibitor of PKCβ (IC50 = 6 nM)

Enzastaurin – 5 mg

Brand:
Cayman
CAS:
170364-57-5
Storage:
-20
UN-No:
Non-Hazardous - /

Enzastaurin is a potent inhibitor of PKCβ (IC50 = 6 nM), with modest selectivity over PKCα, PKCγ, and PKCε (IC50 = 39, 83, and 110 nM, respectively).{24308} At 3 µM, enzastaurin also inhibits signaling through the Akt pathway.{24306} It suppresses angiogenesis, induces apoptosis, and reduces proliferation of cultured tumor cells.{24308,24306} Because of these effects, enzastaurin has potential antineoplastic activity.{24307}  

 

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SKU: 11601 - 5 mg Category:

Description

A potent inhibitor of PKCβ (IC50 = 6 nM), with modest selectivity over PKCα, γ, and ε (IC50 = 39, 83, and 110 nM, respectively); at 3 µM, also inhibits signaling through the Akt pathway; suppresses angiogenesis, induces apoptosis, and reduces proliferation of cultured tumor cells

Formal name: 3-(1-methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione

Synonyms:  LY317615

Molecular weight: 515.6

CAS: 170364-57-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PKC Signaling

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