A potent pan inhibitor of class I catalytic subunits of PI3K

GDC-0941 – 100 mg

Brand:
Cayman
CAS:
957054-30-7
Storage:
-20
UN-No:
Non-Hazardous - /

The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival.{13740,17822} GDC-0941 is a potent pan inhibitor of class I catalytic subunits of PI3K, inhibiting p110α, β, δ, and γ with IC50 values of 3, 33, 3, and 75 nM, respectively.{24602,24604} It is much less effective against class II-IV isoforms of PI3K and against mTOR.{24602,24603} GDC-0941 inhibits the growth of certain types of cancer cells and blocks signaling through PI3K to Akt, both in cells and in vivo.{24602,24605}  

 

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SKU: 11600 - 100 mg Category:

Description

A potent pan inhibitor of class I catalytic subunits of PI3K, inhibiting p110α, β, δ, and γ with IC50 values of 3, 33, 3, and 75 nM, respectively; inhibits the growth of certain types of cancer cells, and blocks signaling through PI3K to Akt, both in cells and in vivo

Formal name: 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine

Synonyms:  GNE-0941|Pictilisib|Pictrelisib

Molecular weight: 513.6

CAS: 957054-30-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Lipid Biochemistry|Glycerophospholipids|Phosphatidyl Inositol Kinases & Phosphatases

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