A non-steroidal androgen receptor antagonist (IC50 = 36 nM); reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators

MDV 3100 – 10 mg

Brand:
Cayman
CAS:
915087-33-1
Storage:
-20
UN-No:
Non-Hazardous - /

MDV 3100 is a non-steroidal androgen receptor antagonist (IC50 = 36 nM).{24601,24600} It reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.{24601} It is orally available and induces tumor regression in mouse models of castration-resistant human prostate cancer.{24601} It has applications in advanced cancers that remain dependent on androgen receptor signaling even in the absence of androgen.{24599}  

 

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SKU: 11596 - 10 mg Category:

Description

A non-steroidal androgen receptor antagonist (IC50 = 36 nM); reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators

Formal name: 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methyl-benzamide

Synonyms:  Enzalutamide

Molecular weight: 464.4

CAS: 915087-33-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Androgens

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