A selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM); orally bioavailable

AZD 8330 – 5 mg

Brand:
Cayman
CAS:
869357-68-6
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells.{32893} AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.{32894}  

 

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SKU: 11588 - 5 mg Category:

Description

A selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM); orally bioavailable, inhibiting ERK phosphorylation in vivo and tumor growth in a Calu-6 nude rat xenograft model

Formal name: 2-[(2-fluoro-4-iodophenyl)amino]-1,6-dihydro-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide

Synonyms:  ARRY-424704

Molecular weight: 461.2

CAS: 869357-68-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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