An aromatase inhibitor (IC50 = 2 nM); inhibits proliferation of ER+ MCF-7 cells at 0.1-100 nM; inhibits proliferation of MCF-7 cells when used at 10 nM in combination with testosterone or 4-androstene-3

Letrozole – 10 mg

Brand:
Cayman
CAS:
112809-51-5
Storage:
-20
UN-No:
Non-Hazardous - /

Letrozole is a potent, cell-permeable inhibitor of aromatase (IC50 = 2 nM).{23490} It inhibits proliferation of estrogen receptor-positive (ER+) MCF-7 cells when used alone at concentrations ranging from 0.1 to 100 nM and when used at a concentration of 10 nM in combination with testosterone or 4-androstene-3,17-dione.{46076} It also reduces matrix metalloproteinase-2 (MMP-2) and MMP-9 levels in MCF-7 cells when used at a concentration of 10 nM. Letrozole (10 µg per day) reduces tumor growth in an MCF-7Ca ovariectomized-mouse xenograft model.{46077} Formulations containing letrozole have been used in the treatment of postmenopausal breast cancer.{23489}  

 

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SKU: 11568 - 10 mg Category:

Description

An aromatase inhibitor (IC50 = 2 nM); inhibits proliferation of ER+ MCF-7 cells at 0.1-100 nM; inhibits proliferation of MCF-7 cells when used at 10 nM in combination with testosterone or 4-androstene-3,17-dione; reduces MMP-2 and MMP-9 levels in MCF-7 cells at 10 nM; reduces tumor growth in an MCF-7Ca ovariectomized-mouse xenograft model at 10 µg per day

Formal name: 4,4′-(1H-1,2,4-triazol-1-ylmethylene)bis-benzonitrile

Synonyms:  CGS 20267

Molecular weight: 285.3

CAS: 112809-51-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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