A potent psychoactive analog of 5-methoxy DiPT and AMT that inhibits re-uptake (IC50s = 0.18

5-methoxy AMT – 25 mg

Brand:
Cayman
CAS:
1137-04-8
Storage:
-20
UN-No:
Non-Hazardous - /

5-methoxy AMT (5-MeO AMT) is a potent psychoactive analog of 5-methoxy DiPT (Item No. 11865) and α-methyltryptamine (AMT), tryptamine derivatives that inhibit reuptake and stimulate release of monoamines.{19758} 5-MeO AMT inhibits re-uptake (IC50s = 0.18, 2.9, and 3.37 μM) and stimulates release (EC50s = 1.5, 460, and 8.9 μM) of dopamine, serotonin, and norepinephrine, respectively from rat brain synaptosomes.{19758} 5-MeO AMT, sometimes called Alpha-O, has been sold under the guise of LSD and abused as a recreational drug.{21059} This tryptamine analog is intended only to be used to aid the forensic analysis of samples that may contain this compound or for scientific research applications.  

 

Available on backorder

Add to quotes
SKU: 11553 - 25 mg Category:

Description

A potent psychoactive analog of 5-methoxy DiPT and AMT that inhibits re-uptake (IC50s = 0.18, 2.9, and 3.37 μM) and stimulates release (EC50s = 1.5, 460, and 8.9 μM) of dopamine, serotonin, and norepinephrine, respectively from rat brain synaptosomes

Formal name: 5-methoxy-α-methyl-1H-indole-3-ethanamine

Synonyms:  5-MeO AMT

Molecular weight: 204.3

CAS: 1137-04-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Drugs of Abuse||Research Area|Forensic Chemistry & Toxicology|Hallucinogens|Tryptamines

Related products

  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 25 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 25 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 100 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 10 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 10 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 10 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page