A potent

ABT-737 – 1 mg

Brand:
Cayman
CAS:
852808-04-9
Storage:
-20
UN-No:
Non-Hazardous - /

The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains.{24784} ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki death proteins, leading to apoptosis.{24783} ABT-737, alone, can induce regression of some tumors in some xenograft mouse models of cancer.{24783,24784} It shows synergy with diverse therapeutics and radiation to trigger apoptosis in cancer cells and xenografts.{24783,15632,24296}  

 

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SKU: 11501 - 1 mg Category:

Description

A potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki death proteins, leading to apoptosis

Formal name: 4-[4-[(4′-chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide

Synonyms: 

Molecular weight: 813.4

CAS: 852808-04-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis

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