A potent

ABT-263 – 1 mg

Brand:
Cayman
CAS:
923564-51-6
Storage:
-20
UN-No:
Non-Hazardous - /

The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains.{24784} ABT-263 is a potent, orally bioavailable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki death proteins, like Bim, leading to apoptosis.{24781,24784} ABT-263, alone, can induce regression of some tumors in some xenograft mouse models of cancer.{24781,24782} It can also potentiate the therapeutic efficacy of chemotherapeutic compounds.{24781,24780} Interestingly, ABT-263 induces apoptosis in cancer cell lines expressing mutants of β-catenin 1, a Wnt signaling factor commonly mutated in a range of cancer types.{24786}  

 

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SKU: 11500 - 1 mg Category:

Description

A potent, orally bioavailable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki death proteins, like Bim, leading to apoptosis; induces apoptosis in cancer cell lines expressing mutants of β-catenin 1

Formal name: 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-benzamide

Synonyms:  A-855071|Navitoclax

Molecular weight: 974.6

CAS: 923564-51-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis

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