A potent inhibitor of the non-receptor tyrosine kinases Abl and Src as well as other members of the Src family; inhibits Abl

Dasatinib – 100 mg

Brand:
Cayman
CAS:
302962-49-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Dasatinib is a potent inhibitor of the non-receptor tyrosine kinases Abl and Src as well as other members of the Src family.{24166,24167} It is effective at sub-nanomolar concentrations, inhibiting Src, Abl, and Lck with IC50 values of 0.05, 0.5, and 0.4 nM, respectively.{24166,24156,24168} At nanomolar concentrations, dasatinib also blocks the activity of several other receptor and non-receptor tyrosine kinases, plus drug resistant mutants.{24156,24168} Because of these activities, dasatinib has potential therapeutic value in diseases that are characterized by elevated levels of these kinases, including some forms of cancer and fibrotic disease.{24166,24164,17350,17482}  

 

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SKU: 11498 - 100 mg Category:

Description

A potent inhibitor of the non-receptor tyrosine kinases Abl and Src as well as other members of the Src family; inhibits Abl, Src, and Lck with IC50 values of 0.05, 0.5, and 0.4 nM, respectively; has potential therapeutic value in some forms of cancer and fibrotic disease

Formal name: N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide

Synonyms:  BMS 354825|Sprycel

Molecular weight: 488

CAS: 302962-49-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Abl Family & Bcr-Abl||Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Abl family & Bcr-Abl Signaling||Research Area|Cancer|Cell Signaling|SRC Family Signaling||Research Area|Cell Biology|Cell Signaling

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