A small molecule that suppresses transactivation of survivin through direct binding to its promoter; induces apoptosis in p53-deficient cancer cells in vitro at 10 nM with little effect on expression levels of other IAP- or Bcl-2-related proteins

YM-155 – 1 mg

Brand:
Cayman
CAS:
781661-94-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important role in drug resistance and cancer cell survival in many types of cancer. YM-155 is a novel small molecule that suppresses transactivation of survivin through direct binding to its promoter.{22213} It selectively suppresses expression of survivin and induces apoptosis in p53-deficient cancer cells in vitro at 10 nM.{22212} At concentrations up to 100 nM, YM-155 has little effect on expression levels of other IAP- or Bcl-2-related proteins.{22212} YM-155 exerts anti-tumor effects in various in vivo cancer models, including prostate, pancreatic, and lung cancer.{22212,22211}  

 

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SKU: 11490 - 1 mg Category:

Description

A small molecule that suppresses transactivation of survivin through direct binding to its promoter; induces apoptosis in p53-deficient cancer cells in vitro at 10 nM with little effect on expression levels of other IAP- or Bcl-2-related proteins

Formal name: 4,9-dihydro-1-(2-methoxyethyl)2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium, bromide

Synonyms:  Sepantronium bromide

Molecular weight: 443.3

CAS: 781661-94-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Transcription Factors

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