A selective Haspin protein kinase inhibitor (IC50 = 2 nM)

CHR-6494 – 1 mg

Brand:
Cayman
CAS:
1333377-65-3
Storage:
-20
UN-No:
Non-Hazardous - /

CHR-6494 is a haspin protein kinase inhibitor (IC50 = 2 nM) selective over 27 other protein kinases, including Aurora B kinase (IC50 > 1 µM). Haspin is a kinase necessary for mitosis that selectively phosphorylates histone 3 at the threonine 3 residue (H3T3ph).{20471} CHR-6494 decreases phosphorylation of H3T3 and arrests the cell cycle in the G2/M phase, which leads to apoptosis. It showed promising results in a xenograft tumor model.  

 

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SKU: 11478 - 1 mg Category:

Description

A selective Haspin protein kinase inhibitor (IC50 = 2 nM), selective over 27 other protein kinases, including Aurora B kinase (IC50 > 1 µM),

Formal name: 3-(1H-indazol-5-yl)-N-propyl-imidazo[1,2-b]pyridazin-6-amine

Synonyms: 

Molecular weight: 292.3

CAS: 1333377-65-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Death|Apoptosis

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