Source: recombinant protein expressed in E. coli. An N-terminal His-tag and SUMOpro tag were removed by cleavage with SUMO protease 1 (Ulp1). • Mr: 12.4 kDa

Irisin (human recombinant) – 100 µg

Brand:
Cayman
CAS:
9037-90-5
Storage:
-80
UN-No:
Non-Hazardous - /

Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1α (PGC-1α), regulates mitochondrial biogenesis and function.{21133} Expression of the membrane protein Fibronectin type III domain-containing protein 5 (FNDC5) is stimulated in muscle by PGC-1α in response to exercise. FNDC5 is proteolytically cleaved and secreted as the hormone peptide irisin (named after the Greek goddess messenger Iris). Irisin has been shown to convert white adipose fat to brown adipose fat upon physical exertion. Brown adipose fat allows for mitochondrial uncoupling leading to thermogenetic programs and heat expenditure.{20433} The physiological responses induced by the effects of irisin have the potential to increase weight loss and reduce insulin resistance and obesity.  

 

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SKU: 11451 - 100 µg Category:

Description

Source: recombinant protein expressed in E. coli. An N-terminal His-tag and SUMOpro tag were removed by cleavage with SUMO protease 1 (Ulp1). • Mr: 12.4 kDa

Formal name:

Synonyms:  Fibronectin Type III Domain 5|FNDC5|FRCP2|PeP

Molecular weight: 0

CAS: 9037-90-5

Purity: ≥90% estimated by SDS-PAGE

Formulation:

Application||Product Type|Proteins|Enzymes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Endocrinology & Metabolism|Thermogenesis

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