A trichothecene mycotoxin; decreases toll-like receptor expression and LPS-induced production of IL-1β

T-2 Toxin – 5 mg

Brand:
Cayman
CAS:
21259-20-1
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium.{20907} It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC50 = 19.47), primary pig alveolar macrophages (PAMs).{20906} In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg).{20907} It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.  

 

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SKU: 11444 - 5 mg Category:

Description

A trichothecene mycotoxin; decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and NO in, and is cytotoxic to (IC50 = 19.47), primary PAMs; induces production of ROS, lipid peroxidation, and GSH depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg); has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage

Formal name: (3α,4β,8α)-12,13-epoxy-4,15-diacetate 8-(3-methylbutanoate)trichothec-9-ene-3,4,8,15-tetrol

Synonyms:  Fusariotoxin T-2|Insariotoxin|Mycotoxin T-2|NSC 138780

Molecular weight: 466.6

CAS: 21259-20-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cell Biology|Cell Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione||Research Area|Toxicology|Cell Health & Viability||Research Area|Toxicology|Environmental|Agriculture

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