An antitumor antibiotic that crosslinks double stranded DNA and is widely used as a tool to selectively inhibit DNA synthesis and mutagenensis

Mitomycin C – 5 mg

Brand:
Cayman
CAS:
50-07-7
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Mitomycin C (MMC) is an antitumor antibiotic that was discovered as a fermentation product of S. caespitosus.{20830} As an alkylating agent, its activity depends on reductive activation either through low pH or DT-diaphorase or NADH cytochrome c reductase.{20829} Activated MMC crosslinks double stranded DNA and is widely used as a tool to selectively inhibit DNA synthesis and mutagenensis, to stimulate genetic recombination, chromosome breakage and sister chromatid exchange, and to induce DNA repair.{20826,20827} MMC has clinical significance in combination cancer chemotherapy of solid tumors as well as for modulating wound healing after ophthalmological surgeries and in the management of various corneal disorders.{20828,20831}  

 

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SKU: 11435 - 5 mg Category:

Description

An antitumor antibiotic that crosslinks double stranded DNA and is widely used as a tool to selectively inhibit DNA synthesis and mutagenensis, to stimulate genetic recombination, chromosome breakage and sister chromatid exchange, and to induce DNA repair

Formal name: 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1aS,2,8S,8aR,8bS-hexahydro-8a-methoxy-5-methyl-azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione

Synonyms:  Ametycine|MitoExtra|Mitonco|Mitoplus|MMC|NSC 26980

Molecular weight: 334.3

CAS: 50-07-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|DNA Damage and Repair|DNA Alkylating Agents||Research Area|Neuroscience|Ophthalmology

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