An immunosuppressive mycotoxin with diverse biological activities; inhibits 20S proteasomal chymotrypsin activity (IC50 = 10 μM); induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils; presses viral infection by Nipah and Hendra virus in HEK293T cells (IC50s = 149 and 579 nM

Gliotoxin – 10 mg

Brand:
Cayman
CAS:
67-99-2
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi with diverse biological activities.{21692,21695,21694,21690,21693,21689,43859,21714} It inhibits 20S proteasomal chymotrypsin activity (IC50 = 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB.{21695,21694} Gliotoxin induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils.{21690,21693} It suppresses viral infection by Nipah and Hendra virus in HEK293T cells (IC50s = 149 and 579 nM, respectively).{21689} Under reducing conditions, gliotoxin inhibits leukotriene A4 hydrolase (LTA4H; Item No. 10007817) epoxide hydrolase activity, but not aminopeptidase activity, and leukotriene B4 (LTB4; Item No. 20110) synthesis in neutrophils and monocytes.{43859} In vivo, gliotoxin (5 mg/kg) reduces LTB4 plasma levels and blocks peritoneal neutrophil infiltration in a mouse model of peritonitis induced by zymosan A (Item No. 21175). It also inhibits geranylgeranyltransferase I and farnesyltransferase (IC50s = 17 and 80 μM, respectively).{21714}  

 

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SKU: 11433 - 10 mg Category:

Description

An immunosuppressive mycotoxin with diverse biological activities; inhibits 20S proteasomal chymotrypsin activity (IC50 = 10 μM); induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils; presses viral infection by Nipah and Hendra virus in HEK293T cells (IC50s = 149 and 579 nM, respectively); inhibits LTA4H epoxide hydrolase activity and LTB4 synthesis n neutrophils and monocytes under reducing conditions; reduces LTB4 plasma levels and blocks peritoneal neutrophil infiltration in a mouse model of zymosan A-induced peritonitis at 5 mg/kg; inhibits geranylgeranyltransferase I and farnesyltransferase (IC50s = 17 and 80 μM, respectively)

Formal name: 2,3R,5aS,6S-tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10aR-epidithiopyrazino[1,2-a]indole-1,4-dione

Synonyms:  Aspergillin

Molecular weight: 326.4

CAS: 67-99-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Immunology & Inflammation|Immunosuppressants||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Infectious Disease|Viral Diseases

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