A membrane active peptide antibiotic of the peptaibol class that strongly induces helical peptide structures and forms voltage-gated ion channels in the lipid bilayers of cell membranes; often used to study ion channel assembly

Alamethicin – 10 mg

Brand:
Cayman
CAS:
27061-78-5
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Alamethicin is an antibiotic peptide belonging to a class of membrane active peptides of fungal origin called peptaibols.{20878} It contains an unusual amphiphilic amino acid, 2-aminoisobutyric acid, which strongly induces helical peptide structures and forms voltage-gated ion channels in the lipid bilayers of cell membranes.{20878} Alamethicin is often used to study ion channel assembly, voltage gating, and peptide-membrane interactions.{20877,20879,20876,20875} Alamethicin is also widely used as agent to induce various physiological and defense responses in eukaryotic cells including plants.{20878}  

 

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SKU: 11425 - 10 mg Category:

Description

A membrane active peptide antibiotic of the peptaibol class that strongly induces helical peptide structures and forms voltage-gated ion channels in the lipid bilayers of cell membranes; often used to study ion channel assembly, voltage gating, and peptide-membrane interactions as well as to induce defense responses in plants

Formal name: (3S,12R)-1-((S)-1-((6S,12S,15S,21S,30S)-1-((R)-1-(2-acetamido-2-methylpropanoyl)pyrrolidin-2-yl)-15-(3-amino-3-oxopropyl)-30-isobutyl-21-isopropyl-3,3,6,9,9,12,18,18,24,24,33,33-dodecamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-2,5,8,11,14,17,20,23,26,29,32-undecaazatetratriacontan-34-oyl)pyrrolidin-2-yl)-12-(((R)-5-amino-1-(((S)-1-hydroxy-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)carbamoyl)-3-isopropyl-6,6,9,9-tetramethyl-1,4,7,10-tetraoxo-2,5,8,11-tetraazapentadecan-15-oic acid

Synonyms:  Antibiotic U-22324

Molecular weight: 1,964.30

CAS: 27061-78-5

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Peptides||Research Area|Plant Biology

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