A tremorgenic fungal toxin that acts as an inhibitor of the large conductance calcium-activated potassium channel BKCa (SLO1

Penitrem A – 1 mg

Brand:
Cayman
CAS:
12627-35-9
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Penitrem A is a tremorgenic fungal toxin that acts as an inhibitor of the large conductance calcium-activated potassium channel BKCa (SLO1, Maxi-K, KCa1.1), inhibiting the binding of charybdotoxin with an IC50 value of 1.7 μM.{20613} It is currently used to evaluate the role of BKCa-mediated potassium flux in various cell processes and responses.{20622,20623}  

 

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SKU: 11347 - 1 mg Category:

Description

A tremorgenic fungal toxin that acts as an inhibitor of the large conductance calcium-activated potassium channel BKCa (SLO1, Maxi-K, KCa1.1), inhibiting the binding of charybdotoxin with an IC50 value of 1.7 μM

Formal name: (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4′,4’a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol

Synonyms:  NSC 354845|Tremortin A

Molecular weight: 634.2

CAS: 12627-35-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Toxins||Research Area|Cardiovascular System|Vasculature||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Neuroscience

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