An indole diterpene which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels

Paxilline – 1 mg

Brand:
Cayman
CAS:
57186-25-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels, as shown in patch clamp (Ki = 1.9 nM) and whole smooth muscle cell studies (Ki = 35.7 nM).{20615,20614} It also enhances the binding of charybdotoxin (Item No. 24115), a peptidyl neurotoxin, to BKCa channels.{20613} Paxilline is currently used to evaluate the role of BKCa channels in various cell processes and responses.{20612,20616}  

 

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SKU: 11345 - 1 mg Category:

Description

An indole diterpene which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels, as shown in patch clamp (Ki = 1.9 nM) and whole smooth muscle cell studies (Ki = 35.7 nM)

Formal name: 5,6,6a,7,12,12bS,12cR,13,14,14aS-decahydro-4bS-hydroxy-2R-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-1-benzopyrano[5’,6’:6,7]indeno[1,2-b]indole-3(4bH)-one

Synonyms: 

Molecular weight: 435.6

CAS: 57186-25-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Neuroscience

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