An inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types (average GI50 = 270 nM); exhibits antifungal

Oligomycin A – 5 mg

Brand:
Cayman
CAS:
579-13-5
Storage:
-20
UN-No:
Non-Hazardous - /

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin A, a dominant analog of the isomers, is an inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types (average GI50 = 270 nM).{20629,20630,20628} Oligomycin A exhibits antifungal, antitumor, and nematocidal activities, but has poor solubility in water and other biocompatible solvents, which limits its clinical application.{20624}  

 

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SKU: 11342 - 5 mg Category:

Description

An inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types (average GI50 = 270 nM); exhibits antifungal, antitumor, and nematocidal activities, but has poor solubility in water and other biocompatible solvents

Formal name: (1S,2’R,4E,5’R,6R,6’S,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,28R,29S)-22-ethyl-3′,4′,5′,6′-tetrahydro-7,11,14,15-tetrahydroxy-6′-[(1Z)-2-hydroxy-1-propen-1-yl]-5′,6,8,10,12,14,16,28,29-nonamethyl-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2′-[2H]pyran]-3,9,13-trione

Synonyms:  MCH 32

Molecular weight: 791.1

CAS: 579-13-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology

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