An anthroquinone derivative found in St. John’s wort; inhibits neuronal uptake of serotonin

Hypericin – 1 mg

Brand:
Cayman
CAS:
548-04-9
Storage:
-20
UN-No:
Non-Hazardous - /

An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities.{34622,34621} Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects.{34620} It exerts broad spectrum phototoxic affects (IC50 = 140 – 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells.{34623} Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.{34634}  

 

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SKU: 11334 - 1 mg Category:

Description

An anthroquinone derivative found in St. John’s wort; inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA, and L-glutamate; broad spectrum phototoxic effects (IC50 = 140-1570 nM) in cancer cells; induces apoptotic signaling and formation of ROS; in vitro antiviral activity against HIV, influenza, hepatitis C, murine cytolomegalovirus, and herpes viruses

Formal name: 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-phenanthro[1,10,9,8-opqra]perylene-7,14-dione

Synonyms:  NSC 407313

Molecular weight: 504.5

CAS: 548-04-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Infectious Disease|Viral Diseases|HSV||Research Area|Infectious Disease|Viral Diseases|Influenza||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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