A mycotoxin and SERCA inhibitor (IC50 = 0.6 µM); induces ptosis

Cyclopiazonic Acid – 10 mg

Brand:
Cayman
CAS:
18172-33-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50 = 0.6 µM).{20510,20511} In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg), in rats.{61119} It induces tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg.  

 

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SKU: 11326 - 10 mg Category:

Description

A mycotoxin and SERCA inhibitor (IC50 = 0.6 µM); induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg), in rats from 11-14 mg/kg

Formal name: 10-acetyl-2,6,6aR,7,11aS,11bR-hexahydro-11-hydroxy-7,7-dimethyl-9H-pyrrolo[1′,2′:2,3]isoindolo[4,5,6-cd]indol-9-one

Synonyms:  CPA|NSC 117181

Molecular weight: 336.4

CAS: 18172-33-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Toxicology|Cell Health & Viability

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