An inhibitor of USP14 and UCHL5

b-AP15 – 1 mg

Brand:
Cayman
CAS:
1009817-63-3
Storage:
-20
UN-No:
Non-Hazardous - /

Proteasome-associated deubiquitinases (DUBs) release ubiquitin from proteasome-targeted ubiquitinated proteins, regenerating free ubiquitin.{25593} b-AP15 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.{20322} It inhibits DUB activity in purified 19S proteasomes with an IC50 value of 2.1 µM.{20322} It exhibits little or no activity against several other DUBs.{20322} Through its effects on USP14 and UCHL5, b-AP15 blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia.{20322,25591} b-AP15 also renders tumor cells sensitive to TNF-mediated apoptosis by natural killer and T cells.{25592}  

 

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SKU: 11324 - 1 mg Category:

Description

An inhibitor of USP14 and UCHL5, two proteasome-associated deubiquitinases; inhibits DUB activity in purified 19S proteasomes with an IC50 value of 2.1 µM; blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia

Formal name: 3E,5E-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-4-piperidinone

Synonyms: 

Molecular weight: 419.4

CAS: 1009817-63-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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