Description
A mycotoxin with diverse biological activities; active against S. aureus, MRSA, rifampicin-resistant S. aureus, and vancomycin-resistant E. faecium (MICs = 1.95, 3.9, 0.97, and 7.81 µg/ml, respectively), as well as C. neoformans (MIC = 3.9 µg/ml); induces ROS production, mitochondrial membrane potential loss, and apoptosis in HepG2 cells at 30 µM and is cytotoxic to a variety of cells in vitro; reduces glutamate-induced excitotoxicity in primary rat cortical neurons at 0.1-1,000 nM; inhibits LPS-induced NO production in RAW 264.7 cells at 0.625-40 µM; toxic to brine shrimp larvae (LD50 = 96 µg/ml); toxic to rats and mice (oral LD50s = 50 and 87-105 mg/kg, respectively)
Formal name: (3R,4S)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid
Synonyms: (–)-Citrinin|CTN|NSC 186
Molecular weight: 250.3
CAS: 518-75-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cardiovascular System|Heart||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Fungal Diseases||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen||Research Area|Toxicology|Cell Health & Viability|Mitochondrial (dys)Function
