A fluorescent probe and antitumor agent; displays ex/em of 445/575 nm; specifically binds GC base pairs on DNA; can be used to characterize heterochromatin in plants; cytotoxic against non-small cell lung cancer and cervical cancer in vitro (IC50s = 1

Chromomycin A3 – 1 mg

Brand:
Cayman
CAS:
7059-24-7
Storage:
-20
UN-No:
Non-Hazardous - /

Chromomycin A3 is an anthraquinone antibiotic and antitumor agent isolated from S. griseus that is used as a fluorescent probe for DNA with excitation/emission spectra of 445/575 nm.{36032,36035} Its DNA binding is specific to two or more contiguous GC base pairs, which makes it suitable for characterizing heterochromatin in plants with species-specific AT:GC ratios.{36035,36031} Chromomycin A3 is cytotoxic against non-small cell lung cancer and cervical cancer in vitro (IC50s = 1, 42, 60, and 40 nM for HCC44, A549, ME180, and HeLa cells, respectively).{366034,31081} It also inhibits oxidative stress- and DNA damage-induced neuronal injury by enhancing Sp1 and Sp3 transcription factor binding.{36033}  

 

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SKU: 11315 - 1 mg Category:

Description

A fluorescent probe and antitumor agent; displays ex/em of 445/575 nm; specifically binds GC base pairs on DNA; can be used to characterize heterochromatin in plants; cytotoxic against non-small cell lung cancer and cervical cancer in vitro (IC50s = 1, 42, 60, and 40 nM for HCC44, A549, ME180, and HeLa cells, respectively); inhibits oxidative stress- and DNA damage-induced neuronal injury,

Formal name: (1S)-1-C-[(2S,3S)-7-[[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-D-lyxo-hexopyranosyl)-β-D-lyxo-hexopyranosyl]oxy]-3-[[O-4-O-acetyl-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-5-deoxy-1-O-methyl-D-threo-2-pentulose

Synonyms:  Aburamycin B|CMA3|NSC 58514

Molecular weight: 1,183.30

CAS: 7059-24-7

Purity: ≥98%

Formulation: A powder

Application|Flow Cytometry||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Neuroscience||Research Area|Plant Biology

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