An inhibitor of both α- and β-glucosidases

Castanospermine – 10 mg

Brand:
Cayman
CAS:
79831-76-8
Storage:
-20
UN-No:
Non-Hazardous - /

Glucosidases catalyze the cleavage of individual glucosyl residues from various glycoconjugates, including complex carbohydrates and glycoproteins. Castanospermine is an inhibitor of both α- and β-glucosidases, inhibiting lysosomal and neutral α-glucosidases with Ki values of 0.1 and 10 μM, respectively, and lysosomal and cytosolic β-glucosidases with Ki values of 7 and 40 μM, respectively.{20414} It is effective both in vitro and in vivo.{20410,20409} Through its effects on glucosidases, castanospermine blocks N-linked glycosylation during post-translational modification of proteins, affecting protein trafficking and cell functions that are dependent on glycosylation, including angiogenesis.{20409,20411} Castanospermine also interferes with viral replication and infection that is dependent on glucosidase activity.{16269,20412,20413}  

 

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SKU: 11313 - 10 mg Category:

Description

An inhibitor of both α- and β-glucosidases, inhibiting lysosomal and neutral α-glucosidases with Ki values of 0.1 and 10 μM, respectively, and lysosomal and cytosolic β-glucosidases with Ki values of 7 and 40 μM, respectively; blocks N-linked glycosylation, affecting protein trafficking

Formal name: octahydro-(1S,6S,7R,8R,8aR)-1,6,7,8-indolizinetetrol

Synonyms:  1,6,7,8-Tetrahydroxyoctahydroindolizine|6,7-Diepicastanospermine|6-Epicastanospermine|NSC 625381

Molecular weight: 189.2

CAS: 79831-76-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases

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