A pyrrolidine antibiotic produced by S. griseolus that inhibits protein and DNA synthesis and activates stress-activated protein kinase

Anisomycin – 50 mg

Brand:
Cayman
CAS:
22862-76-6
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Anisomycin is a pyrrolidine antibiotic produced by S. griseolus that inhibits protein and DNA synthesis.{20427} It activates stress-activated protein kinase, MAP kinase, and other signal transduction pathways. At 30 mg/kg, anisomycin displays immunosuppressive activity superior to that of Cyclosporine A, blocking T cell proliferation in skin-transplanted mice.{20426} Through a caspase-8-dependent pathway, anisomycin acts as a potent and specific anoikis sensitizer of malignant epithelial cells resistant to apoptosis upon detachment from the ECM, preventing distal tumor formation in a mouse model of prostate cancer metastases.{20428}  

 

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Description

A pyrrolidine antibiotic produced by S. griseolus that inhibits protein and DNA synthesis and activates stress-activated protein kinase, MAPK, and other signal transduction pathways

Formal name: 2-[(4-methoxyphenyl)methyl]-3-acetate-(2R,3S,4S)-3,4-pyrrolidinediol

Synonyms:  Flagecidin|NSC 76712|Wuningmeisu C

Molecular weight: 265.3

CAS: 22862-76-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Natural Products|Pyrroles||Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Immunosuppressants

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