A water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously; stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms; relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM

NKH477 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
138605-00-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Forskolin (Item No. 11018) is a potent activator of adenylyl cyclase, but it is sparingly soluble in aqueous solutions. NKH477 is a water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously.{20477,20480,20481} Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or sodium/potassium ATPases.{20477} This compound stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms.{20482} NKH477 relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM.{20481}  

 

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SKU: 11214 - 10 mg Category:

Description

A water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously; stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms; relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM

Formal name: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-β-alanine, N,N-dimethyl-oxo-1H-naphtho[2,1-b]pyran-6-yl ester, monohydrochloride

Synonyms:  ​Colforsin Daropate|Adehl|Colforsin Dapropate

Molecular weight: 546.1

CAS: 138605-00-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Cyclases||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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