Structurally mimics 2-OG and chelates zinc; blocks the activity of 2-OG oxygenases (certain lysine demethylases and hydroxylases); inhibits several Jumonji domain-containing lysine demethylases at low micromolar concentrations and prolyl hydroxlase 1 (IC50 = 1.5 µM)

2,4-Pyridinedicarboxylic Acid (hydrate) – 5 g

Brand:
Cayman
CAS:
207671-42-9
Storage:
-20
UN-No:
Non-Hazardous - /

2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes.{23685,23686} As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl).{23686,23688} 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations.{23695,20945,23687} Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation.{23686,18511} It can inhibit zinc-dependent enzymes, like metallo-β-lactamase.{23684} 2,4-PDCA also affects and is translocated by organic anion transporters.{23689}  

 

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SKU: 11138 - 5 g Category:

Description

Structurally mimics 2-OG and chelates zinc; blocks the activity of 2-OG oxygenases (certain lysine demethylases and hydroxylases); inhibits several Jumonji domain-containing lysine demethylases at low micromolar concentrations and prolyl hydroxlase 1 (IC50 = 1.5 µM)

Formal name: 2,4-pyridinedicarboxylic acid, monohydrate

Synonyms:  2,4-Dicarboxylpyridine|2,4-PDCA

Molecular weight: 185.1

CAS: 207671-42-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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