A potent inhibitor of both human and mouse soluble epoxide hydrolase (IC50 = 3.7 and 2.8 nM

TPPU – 10 mg

Brand:
Cayman
CAS:
1222780-33-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects.{14072,12607} TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively).{18630} The pharmacokinetics of this compound are dramatically superior to those of the 1-adamantylurea based inhibitors, like AUDA.{18630,20116}  

 

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SKU: 11120 - 10 mg Category:

Description

A potent inhibitor of both human and mouse soluble epoxide hydrolase (IC50 = 3.7 and 2.8 nM, respectively); has superior pharmacokinetics compared to the 1-adamantylurea based inhibitors, like AUDA

Formal name: N-[1-(1-oxopropyl)-4-piperidinyl]-N’-[4-(trifluoromethoxy)phenyl)-urea

Synonyms: 

Molecular weight: 359.3

CAS: 1222780-33-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Neuroscience|Neuroprotection

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