An L-type calcium channel blocker; reduces amplitude of spontaneous contractions in isolated rabbit ileum at 1 μM; reduces TGF-β-induced calcium oscillations in human fibroblasts at 1 μM; prevents impairment of lung function in a mouse model of bleomycin-induced pulmonary fibrosis at 10 mg/kg per day; reduces increases in mean arterial blood pressure induced by angiotensin II in spontaneously hypertensive rats at 10 μg/kg

Nifedipine – 5 g

Brand:
Cayman
CAS:
21829-25-4
Storage:
-20
UN-No:
Non-Hazardous - /

Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM.{45013} Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877) when administered at a dose of 10 mg/kg per day.{45014} It also reduces increases in mean arterial blood pressure induced by angiotensin II (Item No. 17150) in spontaneously hypertensive rats when administered at a dose of 10 μg/kg.{45015} Formulations containing nifedipine have been used in the treatment of hypertension and angina.  

 

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Description

An L-type calcium channel blocker; reduces amplitude of spontaneous contractions in isolated rabbit ileum at 1 μM; reduces TGF-β-induced calcium oscillations in human fibroblasts at 1 μM; prevents impairment of lung function in a mouse model of bleomycin-induced pulmonary fibrosis at 10 mg/kg per day; reduces increases in mean arterial blood pressure induced by angiotensin II in spontaneously hypertensive rats at 10 μg/kg

Formal name: 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3,5-dimethyl ester

Synonyms:  BAY 1040

Molecular weight: 346.3

CAS: 21829-25-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Angina||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization

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