An oxysterol; suppresses endogenous cholesterol synthesis by preventing SREBP transport to the Golgi; inhibits IgA class switching induced by LPS and various cytokines in B cells (IC50 = ~50 nM); inhibits replication of SARS-CoV-2 in Vero cells (EC50 = 3.675 µM); reduces viral RNA loads in the lung and trachea in a mouse model of SARS-CoV-2 infection at 100 mg/kg per day; serum levels are increased in hACE2 mice in a model of SARS-CoV-2 infection and in a patient with COVID-19

25-hydroxy Cholesterol – 5 mg

Brand:
Cayman
CAS:
2140-46-7
Storage:
-20
UN-No:
Non-Hazardous - /

25-hydroxy Cholesterol is an oxysterol.{20437} It is formed from cholesterol by cholesterol-25-hydroxylase, and its production can be induced by inflammation or infection.{60052} 25-hydroxy Cholesterol suppresses endogenous cholesterol synthesis by binding to insulin-induced gene (INSIG) proteins and preventing sterol regulatory element binding proteins (SREBPs) from being transported to the Golgi. It inhibits IgA class switching induced by LPS and various cytokines in B cells (IC50 = ~50 nM).{20445} 25-hydroxy Cholesterol inhibits replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 3.675 µM) and reduces increases in viral protein production in infected Vero cells when used prior to infection.{60053} It reduces viral RNA loads in the lung and trachea in a mouse model of SARS-CoV-2 infection when administered at a dose of 100 mg/kg per day. Serum levels of 25-hydroxy cholesterol are increased in mice expressing human angiotensin-converting enzyme 2 (hACE2), the functional receptor for SARS-CoV-2, in a model of SARS-CoV-2 infection and in a patient with COVID-19, the primarily respiratory disease caused by SARS-CoV-2.  

 

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Description

An oxysterol; suppresses endogenous cholesterol synthesis by preventing SREBP transport to the Golgi; inhibits IgA class switching induced by LPS and various cytokines in B cells (IC50 = ~50 nM); inhibits replication of SARS-CoV-2 in Vero cells (EC50 = 3.675 µM); reduces viral RNA loads in the lung and trachea in a mouse model of SARS-CoV-2 infection at 100 mg/kg per day; serum levels are increased in hACE2 mice in a model of SARS-CoV-2 infection and in a patient with COVID-19

Formal name: cholest-5-ene-3β,25-diol

Synonyms:  25-OH Cholesterol

Molecular weight: 402.7

CAS: 2140-46-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|COVID-19||Research Area|Infectious Disease|Viral Diseases|Coronaviruses||Research Area|Lipid Biochemistry|Sterol Lipids

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