A long-chain acylcarnitine with both intracellular and extracellular roles; transported into mitochondria to deliver palmitate for fatty acid oxidation; alters calcium mobilization in many cell types; also affects endothelial and epithelial tight junctions

Palmitoyl-DL-carnitine (chloride) – 50 mg

Brand:
Cayman
CAS:
6865-14-1
Storage:
-20
UN-No:
Non-Hazardous - /

Palmitoyl-DL-carnitine is a long-chain acylcarnitine with both intracellular and extracellular roles. Within the cell, palmitoylcarnitine is transported into mitochondria to deliver palmitate for fatty acid oxidation and energy production.{20215} Exogenously added Palmitoyl-DL-carnitine alters calcium mobilization in many cell types.{20218,20222,20221} It also affects endothelial and epithelial tight junctions, reducing resistance and increasing permeability while decreasing cell viability.{20217,20220}  

 

Available on backorder

Add to quotes
SKU: 11095 - 50 mg Category:

Description

A long-chain acylcarnitine with both intracellular and extracellular roles; transported into mitochondria to deliver palmitate for fatty acid oxidation; alters calcium mobilization in many cell types; also affects endothelial and epithelial tight junctions, reducing resistance and increasing permeability

Formal name: 3-carboxy-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-1-propanaminium, chloride

Synonyms:  ​DL-Palmitoylcarnitine|DL-Hexadecanoylcarnitine|Hexadecanoyl-DL-carnitine|NSC 628323

Molecular weight: 436.1

CAS: 6865-14-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Carnitines||Product Type|Biochemicals|Lipids||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Lipid Biochemistry|Fatty Acids|Degradation

Related products

  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 500 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 500 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 25 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 25 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 1 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 1 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 100 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 100 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page