A phenol with diverse biological activities; active against the bacteria B. subtilis

4′-O-Methylhonokiol – 500 µg

Brand:
Cayman
CAS:
68592-15-4
Storage:
-20
UN-No:
De Minimis - 1170 / 3

4′-O-Methylhonokiol is a phenol that has been found in M. grandiflora and has diverse biological activities.{58070,58073,58071,58072} It is active against the bacteria B. subtilis, S. aureus, and M. smegmatis (MIC = 2.5 µg/ml for all) and the fungus T. mentagrophytes (MIC = 1.25 µg/ml).{58070} 4′-O-Methylhonokiol (10 and 30 µM) inhibits LPS-induced activation of NF-kB and production of nitric oxide (NO) in RAW 264.7 macrophages.{58073} In vivo, 4′-O-Methylhonokiol (20 and 200 mg/kg) reduces carrageenan-induced paw edema in mice. It reduces neuronal apoptosis and escape latency in the Morris water maze in a mouse model of Alzheimer’s disease induced by amyloid-β 1-42 (Aβ42) when administered at a dose of 1 mg/kg.{58071} 4-O-methylhonokiol also reduces plasma cholesterol and triglyceride levels, ameliorates hepatic steatosis, and improves insulin resistance in a mouse model of high-fat diet-induced obesity.{58072}  

 

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SKU: 11089 - 500 µg Category:

Description

A phenol with diverse biological activities; active against the bacteria B. subtilis, S. aureus, and M. smegmatis (MIC = 2.5 µg/ml for all) and the fungus T. mentagrophytes (MIC = 1.25 µg/ml); inhibits LPS-induced activation of NF-kB and production of NO in RAW 264.7 macrophages at 10 and 30 µM; reduces carrageenan-induced paw edema in mice at 20 and 200 mg/kg; reduces neuronal apoptosis and escape latency in the Morris water maze in a mouse model of Aβ42-induced Alzheimer’s disease at 1 mg/kg; reduces plasma cholesterol and triglyceride levels, ameliorates hepatic steatosis, and improves insulin resistance in a mouse model of high-fat diet-induced obesity

Formal name: 4′-methoxy-3′,5-di-2-propen-1-yl-[1,1′-biphenyl]-2-ol

Synonyms:  4-Methoxyhonokiol|NSC 293101

Molecular weight: 280.4

CAS: 68592-15-4

Purity: ≥98%

Formulation: A solution in Ethanol

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Polyphenols||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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