A protein kinase C inhibitor with structural similarity to staurosporine; inhibits PKCα (93% kinase activity inhibited at 1 μM )

Bisindolylmaleimide III – 5 mg

Brand:
Cayman
CAS:
137592-43-9
Storage:
-20
UN-No:
Non-Hazardous - /

Bisindolylmaleimide III was developed as a protein kinase C (PKC) inhibitor with structural similarity to the nonspecific PKC inhibitor staurosporine.{17276,17275} At 1 μM, bisindolylmaleimide III inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency.{12847} Additionally, it inhibits PDK1, an important kinase in the insulin signaling pathway, with an IC50 value of 3.8 μM.  

 

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SKU: 11072 - 5 mg Category:

Description

A protein kinase C inhibitor with structural similarity to staurosporine; inhibits PKCα (93% kinase activity inhibited at 1 μM ), PDK1 (IC50 =3.8 μM), S6K1, MAPKAP-K1, RSK2 and MSK1

Formal name: 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Synonyms:  BIM III

Molecular weight: 384.4

CAS: 137592-43-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Kinase Inhibitors|S6K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling

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