Inhibits maize HDACs: HD2

ITF 2357 – 5 mg

Brand:
Cayman
CAS:
732302-99-7
Storage:
-20
UN-No:
Non-Hazardous - /

ITF 2357 inhibits class I and class II histone deacetylases (maize HDACs: HD2, HD-1B, and HD-1A with IC50s = 7.5-16 nM) and reduces the production of several pro-inflammatory cytokines including TNFα, IL-1α, and IL-1β (IC50s = 10-22 nM).{22291} ITF 2357 also has activity against cells expressing janus kinase 2 (JAK2)V617F (IC50s = 1-10 nM), a mutated form of the JAK2 enzyme that is implicated in the pathophysiology of many myeloproliferative diseases, including polycythaemia vera.{22292}  

 

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SKU: 11045 - 5 mg Category:

Description

Inhibits maize HDACs: HD2, HD-1B, and HD-1A (IC50s = 7.5-16 nM) and reduces TNFα, IL-1α, and IL-1β production (IC50s = 10-22 nM); inhibits activity of cells expressing JAK2V617F (IC50s = 1-10 nM), which are implicated in the pathophysiology of many myeloproliferative diseases

Formal name: N-[4-[(hydroxyamino)carbonyl]phenyl]-carbamic acid, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester, monohydrochloride, monohydrate

Synonyms: 

Molecular weight: 476

CAS: 732302-99-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Immunology & Inflammation

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