A bioisostere of 17

CAY10665 – 500 µg

Brand:
Cayman
CAS:
1235543-17-5
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Isolated neonatal rat cardiomyocytes, which spontaneously beat in culture, are used to evaluate the antiarrhythmic effects of polyunsaturated fatty acids (PUFA).{21675} In this model, the ω-3 PUFA eicosapentaenoic acid (EPA, 3-10 μM) reduces the contraction rate of cells, indicating a positive antiarrhythmic effect.{21675} Cytochrome P450 metabolites of EPA are more potent, with 17,18-epoxyeicosatetraenoic acid (17,18-EET) reducing contractions at 30 nM.{18672} CAY10665 is a bioisostere of 17,18-EET which is approximately 50% more effective at reducing arrhythmic contraction frequency, without affecting amplitude, when tested at 30 nM.{19905} This disubstituted oxamide represents a stable analog of 17,18-EET which may be used to study the mechanism of regulation of cardiomyocyte contractility by EPA metabolites.  

 

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SKU: 11044 - 500 µg Category:

Description

A bioisostere of 17,18-EET which is approximately 50% more effective at reducing arrhythmic contraction frequency, without affecting amplitude, when tested at 30 nM

Formal name: 16-[[2-(methylamino)-2-oxoacetyl]amino]-11Z-hexadecenoic acid

Synonyms: 

Molecular weight: 354.5

CAS: 1235543-17-5

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Fatty Acids||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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