A selective

Bafilomycin A1 – 500 µg

Brand:
Cayman
CAS:
88899-55-2
Storage:
-20
UN-No:
Non-Hazardous - /

Bafilomycin A1 is a selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases), blocking these proton pumps in mammalian, plant, or fungal cells with an IC50 value in the 4-400 nM range.{20718} It is at least 1,000-fold less potent at most other types of ATPases.{20718} Bafilomycin A1 also inhibits autophagy by preventing vacuolar acidification necessary for autophagosome maturation.{20721,20720}  

 

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SKU: 11038 - 500 µg Category:

Description

A selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases), blocking these proton pumps in mammalian, plant, or fungal cells with an IC50 value in the 4-400 nM range; also inhibits autophagy by preventing vacuolar acidification necessary for autophagosome maturation

Formal name: (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one

Synonyms:  NSC 381866

Molecular weight: 622.8

CAS: 88899-55-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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